Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial.
Identifieur interne : 000052 ( Main/Exploration ); précédent : 000051; suivant : 000053Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial.
Auteurs : Christian Gold [Norvège] ; Jasmin Eickholt [Allemagne] ; Jörg Assmus [Norvège] ; Brynjulf Stige [Norvège] ; Jo Dugstad Wake [Norvège] ; Felicity Anne Baker [Australie] ; Jeanette Tamplin [Australie] ; Imogen Clark [Australie] ; Young-Eun Claire Lee [Australie] ; Stine Lindahl Jacobsen [Danemark] ; Hanne Mette Ochsner Ridder [Danemark] ; Gunter Kreutz [Allemagne] ; Dorothea Muthesius [Allemagne] ; Thomas Wosch [Allemagne] ; Enrico Ceccato [Italie] ; Alfredo Raglio [Italie] ; Mirella Ruggeri [Italie] ; Annemiek Vink [Pays-Bas] ; Sytse Zuidema [Pays-Bas] ; Helen Odell-Miller [Royaume-Uni] ; Martin Orrell [Royaume-Uni] ; Justine Schneider [Royaume-Uni] ; Christine Kubiak [France] ; Renee Romeo [Royaume-Uni] ; Monika Geretsegger [Norvège]Source :
- BMJ open [ 2044-6055 ] ; 2019.
Descripteurs français
- KwdFr :
- Analyse de regroupements (MeSH), Chant (MeSH), Démence (thérapie), Dépression (thérapie), Essais contrôlés randomisés comme sujet (MeSH), Humains (MeSH), Maisons de repos (MeSH), Maisons de retraite médicalisées (MeSH), Musicothérapie (méthodes), Qualité de vie (MeSH), Sujet âgé (MeSH), Thérapie par le loisir (méthodes), Études multicentriques comme sujet (MeSH), Évaluation gériatrique (MeSH).
- MESH :
- méthodes : Musicothérapie, Thérapie par le loisir.
- thérapie : Démence, Dépression.
- Analyse de regroupements, Chant, Essais contrôlés randomisés comme sujet, Humains, Maisons de repos, Maisons de retraite médicalisées, Qualité de vie, Sujet âgé, Études multicentriques comme sujet, Évaluation gériatrique.
English descriptors
- KwdEn :
- Aged (MeSH), Cluster Analysis (MeSH), Dementia (therapy), Depression (therapy), Geriatric Assessment (MeSH), Homes for the Aged (MeSH), Humans (MeSH), Multicenter Studies as Topic (MeSH), Music Therapy (methods), Nursing Homes (MeSH), Quality of Life (MeSH), Randomized Controlled Trials as Topic (MeSH), Recreation Therapy (methods), Singing (MeSH).
- MESH :
Abstract
INTRODUCTION
In older adults, dementia and depression are associated with individual distress and high societal costs. Music interventions such as group music therapy (GMT) and recreational choir singing (RCS) have shown promising effects, but their comparative effectiveness across clinical subgroups is unknown. This trial aims to determine effectiveness of GMT, RCS and their combination for care home residents and to examine heterogeneity of treatment effects across subgroups.
METHODS AND ANALYSIS
This large, pragmatic, multinational cluster-randomised controlled trial with a 2×2 factorial design will compare the effects of GMT, RCS, both or neither, for care home residents aged 65 years or older with dementia and depressive symptoms. We will randomise 100 care home units with ≥1000 residents in total across eight countries. Each intervention will be offered for 6 months (3 months 2 times/week followed by 3 months 1 time/week), with extension allowed if locally available. The primary outcome will be the change in the Montgomery-Åsberg Depression Rating Scale score at 6 months. Secondary outcomes will include depressive symptoms, cognitive functioning, neuropsychiatric symptoms, psychotropic drug use, caregiver burden, quality of life, mortality and costs over at least 12 months. The study has 90% power to detect main effects and is also powered to determine interaction effects with gender, severity and socioeconomic status.
ETHICS AND DISSEMINATION
Ethical approval has been obtained for one country and will be obtained for all countries. Results will be presented at national and international conferences and published in scientific journals.
TRIAL REGISTRATION NUMBERS
NCT03496675; Pre-results, ACTRN12618000156280.
DOI: 10.1136/bmjopen-2018-023436
PubMed: 30928926
PubMed Central: PMC6475205
Affiliations:
- Allemagne, Australie, Danemark, France, Italie, Norvège, Pays-Bas, Royaume-Uni
- Angleterre, Bavière, Berlin, District de Basse-Franconie, Grand Londres, Groningue (province), Jutland du Nord, Nottinghamshire, Victoria (État), Île-de-France
- Aalborg, Berlin, Groningue, Londres, Melbourne, Nottingham, Paris, Wurtzbourg
- Université d'Aalborg, Université de Groningue, Université de Melbourne, Université de Nottingham
Links toward previous steps (curation, corpus...)
Le document en format XML
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Aalborg</wicri:regionArea><orgName type="university">Université d'Aalborg</orgName><placeName><settlement type="city">Aalborg</settlement><region nuts="2" type="region">Jutland du Nord</region></placeName></affiliation></author><author><name sortKey="Ridder, Hanne Mette Ochsner" sort="Ridder, Hanne Mette Ochsner" uniqKey="Ridder H" first="Hanne Mette Ochsner" last="Ridder">Hanne Mette Ochsner Ridder</name><affiliation wicri:level="4"><nlm:affiliation>Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Communication and Psychology, Aalborg University, Aalborg</wicri:regionArea><orgName type="university">Université d'Aalborg</orgName><placeName><settlement type="city">Aalborg</settlement><region nuts="2" type="region">Jutland du Nord</region></placeName></affiliation></author><author><name sortKey="Kreutz, Gunter" sort="Kreutz, Gunter" uniqKey="Kreutz G" first="Gunter" last="Kreutz">Gunter Kreutz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Music, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Music, Carl von Ossietzky University Oldenburg, Oldenburg</wicri:regionArea><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Muthesius, Dorothea" sort="Muthesius, Dorothea" uniqKey="Muthesius D" first="Dorothea" last="Muthesius">Dorothea Muthesius</name><affiliation wicri:level="3"><nlm:affiliation>Berlin University of the Arts, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin University of the Arts, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wosch, Thomas" sort="Wosch, Thomas" uniqKey="Wosch T" first="Thomas" last="Wosch">Thomas Wosch</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Ceccato, Enrico" sort="Ceccato, Enrico" uniqKey="Ceccato E" first="Enrico" last="Ceccato">Enrico Ceccato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mental Health, Azienda ULSS 8 Berica, Vicenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental Health, Azienda ULSS 8 Berica, Vicenza</wicri:regionArea><wicri:noRegion>Vicenza</wicri:noRegion></affiliation></author><author><name sortKey="Raglio, Alfredo" sort="Raglio, Alfredo" uniqKey="Raglio A" first="Alfredo" last="Raglio">Alfredo Raglio</name><affiliation wicri:level="1"><nlm:affiliation>Music Therapy Research Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Music Therapy Research Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ruggeri, Mirella" sort="Ruggeri, Mirella" uniqKey="Ruggeri M" first="Mirella" last="Ruggeri">Mirella Ruggeri</name><affiliation wicri:level="1"><nlm:affiliation>Public Health and Community Medicine, University of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Public Health and Community Medicine, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Vink, Annemiek" sort="Vink, Annemiek" uniqKey="Vink A" first="Annemiek" last="Vink">Annemiek Vink</name><affiliation wicri:level="4"><nlm:affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Music therapy Department, Academy of Music, ArtEZ University of the Arts, Enschede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Music therapy Department, Academy of Music, ArtEZ University of the Arts, Enschede</wicri:regionArea><wicri:noRegion>Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Zuidema, Sytse" sort="Zuidema, Sytse" uniqKey="Zuidema S" first="Sytse" last="Zuidema">Sytse Zuidema</name><affiliation wicri:level="4"><nlm:affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Odell Miller, Helen" sort="Odell Miller, Helen" uniqKey="Odell Miller H" first="Helen" last="Odell-Miller">Helen Odell-Miller</name><affiliation wicri:level="1"><nlm:affiliation>The Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Orrell, Martin" sort="Orrell, Martin" uniqKey="Orrell M" first="Martin" last="Orrell">Martin Orrell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Mental Health, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Mental Health, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Schneider, Justine" sort="Schneider, Justine" uniqKey="Schneider J" first="Justine" last="Schneider">Justine Schneider</name><affiliation wicri:level="4"><nlm:affiliation>School of Sociology and Social Policy, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Sociology and Social Policy, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Kubiak, Christine" sort="Kubiak, Christine" uniqKey="Kubiak C" first="Christine" last="Kubiak">Christine Kubiak</name><affiliation wicri:level="3"><nlm:affiliation>European Clinical Research Infrastructure Network (ECRIN), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Clinical Research Infrastructure Network (ECRIN), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Romeo, Renee" sort="Romeo, Renee" uniqKey="Romeo R" first="Renee" last="Romeo">Renee Romeo</name><affiliation wicri:level="3"><nlm:affiliation>King's Health Economics, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's Health Economics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Geretsegger, Monika" sort="Geretsegger, Monika" uniqKey="Geretsegger M" first="Monika" last="Geretsegger">Monika Geretsegger</name><affiliation wicri:level="1"><nlm:affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30928926</idno><idno type="pmid">30928926</idno><idno type="doi">10.1136/bmjopen-2018-023436</idno><idno type="pmc">PMC6475205</idno><idno type="wicri:Area/Main/Corpus">000047</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000047</idno><idno type="wicri:Area/Main/Curation">000046</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000046</idno><idno type="wicri:Area/Main/Exploration">000046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial.</title><author><name sortKey="Gold, Christian" sort="Gold, Christian" uniqKey="Gold C" first="Christian" last="Gold">Christian Gold</name><affiliation wicri:level="1"><nlm:affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Eickholt, Jasmin" sort="Eickholt, Jasmin" uniqKey="Eickholt J" first="Jasmin" last="Eickholt">Jasmin Eickholt</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Assmus, Jorg" sort="Assmus, Jorg" uniqKey="Assmus J" first="Jörg" last="Assmus">Jörg Assmus</name><affiliation wicri:level="1"><nlm:affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Stige, Brynjulf" sort="Stige, Brynjulf" uniqKey="Stige B" first="Brynjulf" last="Stige">Brynjulf Stige</name><affiliation wicri:level="1"><nlm:affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Wake, Jo Dugstad" sort="Wake, Jo Dugstad" uniqKey="Wake J" first="Jo Dugstad" last="Wake">Jo Dugstad Wake</name><affiliation wicri:level="1"><nlm:affiliation>NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Baker, Felicity Anne" sort="Baker, Felicity Anne" uniqKey="Baker F" first="Felicity Anne" last="Baker">Felicity Anne Baker</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamplin, Jeanette" sort="Tamplin, Jeanette" uniqKey="Tamplin J" first="Jeanette" last="Tamplin">Jeanette Tamplin</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Clark, Imogen" sort="Clark, Imogen" uniqKey="Clark I" first="Imogen" last="Clark">Imogen Clark</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lee, Young Eun Claire" sort="Lee, Young Eun Claire" uniqKey="Lee Y" first="Young-Eun Claire" last="Lee">Young-Eun Claire Lee</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jacobsen, Stine Lindahl" sort="Jacobsen, Stine Lindahl" uniqKey="Jacobsen S" first="Stine Lindahl" last="Jacobsen">Stine Lindahl Jacobsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Communication and Psychology, Aalborg University, Aalborg</wicri:regionArea><orgName type="university">Université d'Aalborg</orgName><placeName><settlement type="city">Aalborg</settlement><region nuts="2" type="region">Jutland du Nord</region></placeName></affiliation></author><author><name sortKey="Ridder, Hanne Mette Ochsner" sort="Ridder, Hanne Mette Ochsner" uniqKey="Ridder H" first="Hanne Mette Ochsner" last="Ridder">Hanne Mette Ochsner Ridder</name><affiliation wicri:level="4"><nlm:affiliation>Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Communication and Psychology, Aalborg University, Aalborg</wicri:regionArea><orgName type="university">Université d'Aalborg</orgName><placeName><settlement type="city">Aalborg</settlement><region nuts="2" type="region">Jutland du Nord</region></placeName></affiliation></author><author><name sortKey="Kreutz, Gunter" sort="Kreutz, Gunter" uniqKey="Kreutz G" first="Gunter" last="Kreutz">Gunter Kreutz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Music, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Music, Carl von Ossietzky University Oldenburg, Oldenburg</wicri:regionArea><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Muthesius, Dorothea" sort="Muthesius, Dorothea" uniqKey="Muthesius D" first="Dorothea" last="Muthesius">Dorothea Muthesius</name><affiliation wicri:level="3"><nlm:affiliation>Berlin University of the Arts, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Berlin University of the Arts, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wosch, Thomas" sort="Wosch, Thomas" uniqKey="Wosch T" first="Thomas" last="Wosch">Thomas Wosch</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Ceccato, Enrico" sort="Ceccato, Enrico" uniqKey="Ceccato E" first="Enrico" last="Ceccato">Enrico Ceccato</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mental Health, Azienda ULSS 8 Berica, Vicenza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental Health, Azienda ULSS 8 Berica, Vicenza</wicri:regionArea><wicri:noRegion>Vicenza</wicri:noRegion></affiliation></author><author><name sortKey="Raglio, Alfredo" sort="Raglio, Alfredo" uniqKey="Raglio A" first="Alfredo" last="Raglio">Alfredo Raglio</name><affiliation wicri:level="1"><nlm:affiliation>Music Therapy Research Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Music Therapy Research Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ruggeri, Mirella" sort="Ruggeri, Mirella" uniqKey="Ruggeri M" first="Mirella" last="Ruggeri">Mirella Ruggeri</name><affiliation wicri:level="1"><nlm:affiliation>Public Health and Community Medicine, University of Verona, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Public Health and Community Medicine, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Vink, Annemiek" sort="Vink, Annemiek" uniqKey="Vink A" first="Annemiek" last="Vink">Annemiek Vink</name><affiliation wicri:level="4"><nlm:affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Music therapy Department, Academy of Music, ArtEZ University of the Arts, Enschede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Music therapy Department, Academy of Music, ArtEZ University of the Arts, Enschede</wicri:regionArea><wicri:noRegion>Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Zuidema, Sytse" sort="Zuidema, Sytse" uniqKey="Zuidema S" first="Sytse" last="Zuidema">Sytse Zuidema</name><affiliation wicri:level="4"><nlm:affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Odell Miller, Helen" sort="Odell Miller, Helen" uniqKey="Odell Miller H" first="Helen" last="Odell-Miller">Helen Odell-Miller</name><affiliation wicri:level="1"><nlm:affiliation>The Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Orrell, Martin" sort="Orrell, Martin" uniqKey="Orrell M" first="Martin" last="Orrell">Martin Orrell</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Mental Health, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Mental Health, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Schneider, Justine" sort="Schneider, Justine" uniqKey="Schneider J" first="Justine" last="Schneider">Justine Schneider</name><affiliation wicri:level="4"><nlm:affiliation>School of Sociology and Social Policy, University of Nottingham, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Sociology and Social Policy, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Kubiak, Christine" sort="Kubiak, Christine" uniqKey="Kubiak C" first="Christine" last="Kubiak">Christine Kubiak</name><affiliation wicri:level="3"><nlm:affiliation>European Clinical Research Infrastructure Network (ECRIN), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Clinical Research Infrastructure Network (ECRIN), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Romeo, Renee" sort="Romeo, Renee" uniqKey="Romeo R" first="Renee" last="Romeo">Renee Romeo</name><affiliation wicri:level="3"><nlm:affiliation>King's Health Economics, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's Health Economics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Geretsegger, Monika" sort="Geretsegger, Monika" uniqKey="Geretsegger M" first="Monika" last="Geretsegger">Monika Geretsegger</name><affiliation wicri:level="1"><nlm:affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Cluster Analysis (MeSH)</term><term>Dementia (therapy)</term><term>Depression (therapy)</term><term>Geriatric Assessment (MeSH)</term><term>Homes for the Aged (MeSH)</term><term>Humans (MeSH)</term><term>Multicenter Studies as Topic (MeSH)</term><term>Music Therapy (methods)</term><term>Nursing Homes (MeSH)</term><term>Quality of Life (MeSH)</term><term>Randomized Controlled Trials as Topic (MeSH)</term><term>Recreation Therapy (methods)</term><term>Singing (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de regroupements (MeSH)</term><term>Chant (MeSH)</term><term>Démence (thérapie)</term><term>Dépression (thérapie)</term><term>Essais contrôlés randomisés comme sujet (MeSH)</term><term>Humains (MeSH)</term><term>Maisons de repos (MeSH)</term><term>Maisons de retraite médicalisées (MeSH)</term><term>Musicothérapie (méthodes)</term><term>Qualité de vie (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Thérapie par le loisir (méthodes)</term><term>Études multicentriques comme sujet (MeSH)</term><term>Évaluation gériatrique (MeSH)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Music Therapy</term><term>Recreation Therapy</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Musicothérapie</term><term>Thérapie par le loisir</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dementia</term><term>Depression</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Démence</term><term>Dépression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cluster Analysis</term><term>Geriatric Assessment</term><term>Homes for the Aged</term><term>Humans</term><term>Multicenter Studies as Topic</term><term>Nursing Homes</term><term>Quality of Life</term><term>Randomized Controlled Trials as Topic</term><term>Singing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term><term>Chant</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Maisons de repos</term><term>Maisons de retraite médicalisées</term><term>Qualité de vie</term><term>Sujet âgé</term><term>Études multicentriques comme sujet</term><term>Évaluation gériatrique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>In older adults, dementia and depression are associated with individual distress and high societal costs. Music interventions such as group music therapy (GMT) and recreational choir singing (RCS) have shown promising effects, but their comparative effectiveness across clinical subgroups is unknown. This trial aims to determine effectiveness of GMT, RCS and their combination for care home residents and to examine heterogeneity of treatment effects across subgroups.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND ANALYSIS</b></p><p>This large, pragmatic, multinational cluster-randomised controlled trial with a 2×2 factorial design will compare the effects of GMT, RCS, both or neither, for care home residents aged 65 years or older with dementia and depressive symptoms. We will randomise 100 care home units with ≥1000 residents in total across eight countries. Each intervention will be offered for 6 months (3 months 2 times/week followed by 3 months 1 time/week), with extension allowed if locally available. The primary outcome will be the change in the Montgomery-Åsberg Depression Rating Scale score at 6 months. Secondary outcomes will include depressive symptoms, cognitive functioning, neuropsychiatric symptoms, psychotropic drug use, caregiver burden, quality of life, mortality and costs over at least 12 months. The study has 90% power to detect main effects and is also powered to determine interaction effects with gender, severity and socioeconomic status.</p></div><div type="abstract" xml:lang="en"><p><b>ETHICS AND DISSEMINATION</b></p><p>Ethical approval has been obtained for one country and will be obtained for all countries. Results will be presented at national and international conferences and published in scientific journals.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION NUMBERS</b></p><p>NCT03496675; Pre-results, ACTRN12618000156280.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30928926</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>3</Issue><PubDate><Year>2019</Year><Month>03</Month><Day>30</Day></PubDate></JournalIssue><Title>BMJ open</Title></Journal><ArticleTitle>Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial.</ArticleTitle><Pagination><MedlinePgn>e023436</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2018-023436</ELocationID><Abstract><AbstractText Label="INTRODUCTION">In older adults, dementia and depression are associated with individual distress and high societal costs. Music interventions such as group music therapy (GMT) and recreational choir singing (RCS) have shown promising effects, but their comparative effectiveness across clinical subgroups is unknown. This trial aims to determine effectiveness of GMT, RCS and their combination for care home residents and to examine heterogeneity of treatment effects across subgroups.</AbstractText><AbstractText Label="METHODS AND ANALYSIS">This large, pragmatic, multinational cluster-randomised controlled trial with a 2×2 factorial design will compare the effects of GMT, RCS, both or neither, for care home residents aged 65 years or older with dementia and depressive symptoms. We will randomise 100 care home units with ≥1000 residents in total across eight countries. Each intervention will be offered for 6 months (3 months 2 times/week followed by 3 months 1 time/week), with extension allowed if locally available. The primary outcome will be the change in the Montgomery-Åsberg Depression Rating Scale score at 6 months. Secondary outcomes will include depressive symptoms, cognitive functioning, neuropsychiatric symptoms, psychotropic drug use, caregiver burden, quality of life, mortality and costs over at least 12 months. The study has 90% power to detect main effects and is also powered to determine interaction effects with gender, severity and socioeconomic status.</AbstractText><AbstractText Label="ETHICS AND DISSEMINATION">Ethical approval has been obtained for one country and will be obtained for all countries. Results will be presented at national and international conferences and published in scientific journals.</AbstractText><AbstractText Label="TRIAL REGISTRATION NUMBERS">NCT03496675; Pre-results, ACTRN12618000156280.</AbstractText><CopyrightInformation>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gold</LastName><ForeName>Christian</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0002-8654-7474</Identifier><AffiliationInfo><Affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eickholt</LastName><ForeName>Jasmin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assmus</LastName><ForeName>Jörg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stige</LastName><ForeName>Brynjulf</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wake</LastName><ForeName>Jo Dugstad</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>NORCE Norwegian Research Centre, Bergen, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Felicity Anne</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamplin</LastName><ForeName>Jeanette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Imogen</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young-Eun Claire</ForeName><Initials>YC</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Southbank, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobsen</LastName><ForeName>Stine Lindahl</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridder</LastName><ForeName>Hanne Mette Ochsner</ForeName><Initials>HMO</Initials><AffiliationInfo><Affiliation>Department of Communication and Psychology, Aalborg University, Aalborg, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kreutz</LastName><ForeName>Gunter</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0001-9586-241X</Identifier><AffiliationInfo><Affiliation>Department of Music, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muthesius</LastName><ForeName>Dorothea</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Berlin University of the Arts, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wosch</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Faculty of Applied Social Sciences, University of Applied Sciences Würzburg-Schweinfurt, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ceccato</LastName><ForeName>Enrico</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Mental Health, Azienda ULSS 8 Berica, Vicenza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raglio</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-3047-8948</Identifier><AffiliationInfo><Affiliation>Music Therapy Research Laboratory, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruggeri</LastName><ForeName>Mirella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Public Health and Community Medicine, University of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vink</LastName><ForeName>Annemiek</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Music therapy Department, Academy of Music, ArtEZ University of the Arts, Enschede, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuidema</LastName><ForeName>Sytse</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Odell-Miller</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>The Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orrell</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Mental Health, University of Nottingham, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Justine</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Sociology and Social Policy, University of Nottingham, Nottingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubiak</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>European Clinical Research Infrastructure Network (ECRIN), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romeo</LastName><ForeName>Renee</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>King's Health Economics, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geretsegger</LastName><ForeName>Monika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>GAMUT - The Grieg Academy Music Therapy Research Centre, NORCE Norwegian Research Centre, Bergen, Norway.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT03496675</AccessionNumber></AccessionNumberList></DataBank><DataBank><DataBankName>ANZCTR</DataBankName><AccessionNumberList><AccessionNumber>ACTRN12618000156280</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D000078325">Clinical Trial Protocol</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open</MedlineTA><NlmUniqueID>101552874</NlmUniqueID><ISSNLinking>2044-6055</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003704" MajorTopicYN="N">Dementia</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015577" MajorTopicYN="N">Geriatric Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006707" MajorTopicYN="N">Homes for the Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015337" MajorTopicYN="N">Multicenter Studies as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009147" MajorTopicYN="N">Music Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009735" MajorTopicYN="Y">Nursing Homes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057173" MajorTopicYN="N">Recreation Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D063346" MajorTopicYN="Y">Singing</DescriptorName></MeshHeading></MeshHeadingList><KeywordList 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